ncRNA name | hsa-miR-92a-3p |
ncRNA Category | miRNA |
Disease name | uveal melanoma (UM) |
Species | Homo sapiens |
Tissues/Cell_line | UM cell lines OCM-1, OCM-3 and 92.1; UM samples, normal skin specimens |
Methods | qPCR, transfection, Western blot, apoptosis assay |
Expression pattern | down-regulated |
Functional description | MS-275-triggered downregulation of the oncogenic miR-92a-3p- which leads to the overexpression of its target gene MYCBP2 - is an event required for the enhanced susceptibility of melanoma cells to TRAIL-mediated apoptosis. |
PubMed ID | 27620505 |
Year | 2016 |
Title | miR-92a-3p and MYCBP2 are involved in MS-275-induced and c-myc-mediated TRAIL-sensitivity in melanoma cells. |
Drug-related ncRNA | NO |
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